A2984
Sigma
N-Arachidonylmaleimide 
≥98% (HPLC)
| CAS Number: | 876305-42-9 |
| Linear Formula: | C24H35NO2 |
| Molecular Weight: | 369.54 |
| MDL number: | MFCD11521506 |
Description
| Biochem/physiol Actions | N-Arachidonylmaleidmide, NAM, is a potent irreversible inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | under inert gas |
| storage temp. | −20°C |
Safety
References
| reference | Burston JJ, et al., N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. Pharmacol. Ther. 327, 546-553, (2008) |
| Wang Y., et al., A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening. Drug Del. Tech. 6, 387-393, (2008) | |
| Zvonok N., et al., Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis. Chem. Biol. 15, 854-862, (2008) |
